Synthesis and effects of new caffeic acid derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages.

نویسندگان

  • Jie Zhang
  • Liu-Xin Xu
  • Xu-Sheng Xu
  • Bo-Wei Li
  • Rui Wang
  • Jian-Jun Fu
چکیده

In this study, 20 new derivatives of caffeic acid esters were synthesized and their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages were determined. Compounds 3l, 3r, 3s and 3t were found to decrease nitrite levels in a dose-dependent manner in LPS-induced cells and showed potent inhibitory activities against the NO production in RAW264.7 macrophages with IC50 values of 7.4, 5.9, 3.3 and 2.2 μM, respectively. They could be selected as compromising compounds for the later pharmacological study.

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عنوان ژورنال:
  • International journal of clinical and experimental medicine

دوره 7 4  شماره 

صفحات  -

تاریخ انتشار 2014